業績提示

英文原著

* Correspondence author　（当教室員）

2011

  • Miyake K*, Hirasawa T, Soutome M, Itoh M, Goto Y, Endoh K, Takahashi K, Kudo S, Nakawaga T, Yokoi S, Taira T, Inazawa J, Kubota T.The protocadherins, PCDHB1 and PCDH7, are regulated by MeCP2 in neuronal cells and brain tissues: implication for pathogenesis of Rett syndrome. BMC Neurosci (in press)
  • Sakazume S, Ohashi H, Sasaki Y, Harada N, Nakanishi K, Sato H, Emi M, Endoh K, Sohma R, Kido Y, Nagai T, Kubota T. Spread of X-chromosome inactivation into chromosome 15 is associated with Prader-Willi syndrome phenotype in a boy with a t(X;15)(p21.1;q11.2) translocation.Hum Genet (in press).
    • Wu J, Fushimi K, Tokuyama S, Ohno M., Miwa T, Koyama T, Yazawa K,Nagai　K,Matsumoto T, Hirai H, and Kawagishi H.Food-functional Constituents in the fruiting bodies of Stropharia rugosoannulata. Biosci. Biotechnol. Biochem. (in press)
      • Choi J-H, Ozawa N, Yamakawa Y, Nagai K, Hirai H, Kawagishi H. Leccinine A, an endoplasmic reticulum stress suppressive compound from the edible mushroom Leccinum extremiorientale. Tetrahedron. 67: 6649-6653, 2011
        • Wakimoto T., Asakawa T., Akahoshi S., Suzuki T., Nagai K., Kawagishi H., Kan T.Proof of the existence of an unstable amino acid: pleurocybellaziridine in Pleurocybella porrigens. Angew. Chem. Int. Edit. 123: 1200-1202, 2011

        2010

        • Kawaguchi T, Suzuki T, Kobayashi Y, Kodani S,Hirai H, Nagai K , Kawagishi H. Unusual amino scid derivatives from the mushroom Pleurocybella porrigens. Tetrahedron 66 : 504-507, 2010.
        • Choi J. H., Maeda K, Nagai K, Harada E, Kawade M, Hirai H, Kawagishi H.Termitomycamides A to E, fatty acid amides isolated from the mushroom Termitomyces titanicus, suppress endoplasmic reticulum stress. Org. Lett. 12: 5012-5015, 2010.

        2009

        • Yoshida H, Nagai K *.  Induction of apoptotic cell death preferentially in reactive astrocytes by concanavalin A. J Biosci Bioeng 108 : 248-251, 2009.
        • Miyake K, Nagai K *. Inhibition of α-mannosidase attenuates endoplasmic reticulum stress induced neuronal cell death. Neurotoxicol 30: 144-150, 2009.
        • Choi JH, Horikawa M, Okumura H, Kodani S, Nagai K *, Hashizume D, Koshino H, Kawagishi H.  Endoplasmic reticulum (ER) stress protecting compounds from the mushroom Mycoleptodonoides aitchisonii. Tetrahedron　65: 221-224, 2009.
        • Ueda K, Kodani S, Kubo M, Masuno K, Sekiya A, Nagai K *, Kawagishi H. Endoplasmic reticulum (ER) stress-suppressive compounds from scrap cultivation beds of the mushroom Hericium erinaceum. Biosci Biotechnol Biochem 73: 1908-1910, 2009.
        • Hiraoka K, Chen LC, Asakawa D, Takeda S, Kubota T. Direct and real-time surface analysis and imaging of biological samples by probe electrospray. J Surf Anal 15: 279-282, 2009.
        • Okuya M, Kurosawa H, Kubota T, Endoh K,　Ogiwara A, Nonoyama S, Hagiwara S, Sato Y, Matsushita T, Fukushima K, Sugita K, Sato T, Arisaka O. Hematopoietic stem cell transplantation for X-linked thrombocytopenia from mild symptomatic carrier. Bone Marrow Transpl 2009 Aug 17. [Epub ahead of print].
        • Kurosawa H, Okuya M, Matsushita T, Kubota T, Endoh K, Kuwashima S, Hagisawa S, Sato Y, Fukushima K, Sugita K, Okada Y, Park MJ, Hayashi Y, Arisaka O. JAK2V617F mutation-positive childhood essential thrombocythemia associated with cerebral venous sinus thrombosis. J Pediatr Hematol Oncol 31:678-680, 2009.
        • Wati H, Kawarabayashi T, Matsubara E, Kasai A, Hirasawa T, Kubota T, Hagiwara Y, Shogi M, Maeda S.　Transthyretin Accelerates Vascular Abeta Deposition in a Mouse Model of Alzheimer's Disease. Brain Pathol 19 : 48-57, 2009.
        • Sakurada Y, Kubota T, Imasawa M, Tsumura T, Mabuchi F, Tanabe N, Iijima H.　Angiographic lesion size associated with LOC387715 A69S genotype in subfoveal polypoidal choroidal vasculopathy. Retina 29:1522-1526, 2009.

        2008

        • Natori T, Nagai K *.  Endoplasmic reticulum stress upregulates the chondroitin sulfate level which thus prevents neurite extension in C6 glioma and primary cultured astrocytes. Cell Mol Neurobiol 28: 857-866, 2008.
        • Nagai K *, Natori T, Nishino T, Kodaira F.  Epigenetic Disregulation Induces Cell Growth Retardation in Primary Cultured Glial Cells. J Biosci Bioeng 105: 470-475, 2008.
        • Natori T, Kodaira F, Hirasawa T, Gao YY, Nagai K *.  Augmentation of polysialic acid (PSA) by valproate (VPA) in the early postnatal mouse hippocampus and primary cultured hippocampal neurons. J Biosci Bioeng 105: 164-167, 2008.
        • Sakurada Y, Kubota T, Mabuchi F, Imasawa M, Tanabe N, Iijima H. Association of LOC387715 A69S with Vitreous Hemorrhage in Polypoidal Choroidal Vasculopathy. Am J Ophthalmol 145:1058-1062, 2008.
        • Gono T, Yazaki M, Agematu K, Matuda M, Yasui K, Yamaura M, Hidaka F, Mizukami T, Nunoi H, Kubota T, Ikeda S. Adult onset X-linked chronic granulomatous disease in a female patient caused by a de novo mutation in paternal-origin CYBB gene and skewed inactivation of normal maternal X chromosome. Intern Med 43:1053-1056, 2008.
        • Kojima H, Wada T, Seki H, Kubota T, Wakui K, Fukushima Y. One third of Japanese patients with multiple osteochondromas may have mutations in genes other than EXT1 or EXT2. Genet Test 12: 557-561, 2008.
        • Chen LC, Nishidate K, Saito Y, Mori K, Asakawa D, Takeda S, Kubota T, Terada N, Hori H, Hiraoka K. Application of probe electrospray to the real-world samples. Rapid Commun Mass Spectrom 22:2366-2374, 2008.
        • Chen LC, Nishidate K, Saito Y, Mori K, Asakawa D, Takeda S, Kubota T, Terada N, Hori H, Hiraoka K. Characteristics of probe electrosray generated from solid needle. J Phy Chem B 112: 11164-11170, 2008.
        • Takano K, Nakagawa E, Inoue K, Kamada F, Kure S, Goto Y, Inazawa J, Kato M, Kubota T, Kurosawa K, Matsumoto N, Nanba E, Okazawa H, Saitoh S, Wada T.  A loss-of-function mutation in the FTSJ1 gene causes nonsyndromic X-linked mental retardation in a japanese family. Am J Med Genet B Neuropsychiatr Genet 5;147B:479-484, 2008.
        • Ueda K, Tsujimori M, Kodani S, Chiba A, Kubo M, Masuno K, Sekiya A, Nagai K *, Kawagishi H. An endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceum. Bioorg Med Chem 16: 9467-9470, 2008.

        2007

        • Miyake K, Nagai K *.  Phosphorylation of methyl-CpG binding protein 2 (MeCP2) regulates the intracellular localization during neuronal cell differentiation. Neurochem Int 50: 264-270, 2007.
        • Okamoto N, Kubota T, Nakamura Y, Murakami R, Nishikubo T, Tanaka I, Takahashi Y, Hayashi S, Imoto I, Inazawa J, Hosokai N, Kohsaka S, Uchino S. 22q13 microduplication in two patients with common clinical manifestations: A recognizable syndrome? Am J Med Genet A 143:2804-2809, 2007.
        • Ogawa M, Sakashita K, Zhao XY, Hayakawa A, Kubota T, Koike K. Analysis of histone modification around the CpG island region of the p15 gene in acute myeloblastic leukemia. Leuk Res 31:611-621, 2007.
        • Itoh M, Ide S, Takashima S, Kudo S, Nomura Y, Segawa M, Kubota T, Mori I, Tanaka S, Horie H, Tanabe Y, Goto Y.  Methyl CpG-binding protein 2 (a mutation of which causes Rett syndrome) directly regulates insulin-like growth factor binding protein 3 in mouse and human brains. J Neuropathol Exp Neurol 66:117-123. 2007.

        2006

        • Chunshu Y, Endoh K, Soutome M, Kawamura R, Kubota T *. A patient with classic Rett syndrome with a novel mutation in MECP2 exon 1. Clin Genet 70:530-531, 2006.
        • Nagai K *, Chiba A, Nishino T, Kubota T, Kawagishi H.  Dilinoleoyl- phosphatidylethanolamine from Hericium erinaceum protects against ER stress-dependent Neuro2a cell death via protein kinase C pathway. J  Nutr Biochem 17: 525-530, 2006.
        • Imai K, Shimadzu M, Kubota T, Morio T, Matsunaga T, Park YD, Yoshioka A, Nonoyama S.  Female hyper IgM syndrome type 1 with a chromosomal translocation disrupting CD40LG. Biochim Biophys Acta 1762:335-340, 2006.
        • Hiramatsu N, Kasai A, Hayakawa K, Nagai K, Kubota T, Yao J, Kitamura M.  Critical interference by endoplasmic reticulum stress in secreted protein-based reporter assays. J Immunol Methods 315:202-207, 2006.
        • Watanabe K, Yaguchi T, Yang D, Kanno T, Nagai K, Yamamoto S, Fujikawa H, Yamamoto H, Tashiro C, Nishizaki T.  Beneficial effect of intracellular high-mannose oligosaccharides on cryopreservation of mammalian cells and proteins. Cryobiology 53: 330-335, 2006.
        • Uchino S, Wada H, Honda S, Nakamura Y, Ondo Y,Uchiyama T, Tsutsumi M, Suzuki E, Hirasawa T, Kohsaka S．Direct interaction of PDZ domain-containing synaptic molecule Shank3 with GluR1 AMPA receptor J Neurochem 97: 1203-14, 2006.

        2005

        • Nagai K *, Miyake K, Kubota T.  A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth. Brain Res Dev Brain Res 157: 103-106, 2005.
        • Yamanoshita O, Kubota T, Hou J, Ping JH, Zhang XL, Li XP, Li SS, Li XX, Zhu DC, Fukushima Y, Nakajima T. DHPLC is superior to SSCP in screening p53 mutations in esophageal cancer tissues. Int J Cancer 114:74-79, 2005.
        • Hasegawa D, Manabe A, Kubota T, Kawasaki H, Hirose I, Ohtsuka Y, Tsuruta T, Ebihara Y, Goto Y, Zhao XY, Sakashita K, Koike K, Isomura M, Kojima S, Hoshika A, Tsuji K, Nakahata T. Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia. Br J Haematol 128:805-812, 2005.
        • Zhao XY, Sakashita K, Kmijo T, Hidaka E, Sugane K, Kubota T, Koike K. Granulocyte-macrophage colony-stimulating factor induces de novo methylation of the p15 CpG island in hematopietic cells. Cytokine 31:203-212, 2005.
        • Kamitori K, Tanaka M, Okuno-Hirasawa T, Kohsaka S. Receptor related to tylosine kinase RYK regulate cell migration during cortical development. Biochem Biophys Res Commun 330: 446-453, 2005.
        • Hirasawa T, Ohsawa K, Imai Y, Akazawa C, Uchino S, Kohsaka S. Visualization of microglia in living tissue by using Iba1-EGFP transgenic mice. J Neurosci Res 81:357-62, 2005.

        2004以前（主要原著のみ）

        • Kubota T *, Furuumi H, Kamoda T, Iwasaki N, Tobita N, Fujiwara N, Goto Y, Matsui A, Sasaki H, Kajii T. ICF syndrome in a girl with DNA hypomethylation but without detectable DNMT3B mutation. Am J Med Genet 129A:290-293, 2004.
        • Saitoh M, Nagai K, Nakagawa K, Yamamura T, Yamamoto S, Nishizaki T. Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase.  Biochem Pharmacol 67: 2005-2011, 2004.
        • Matsumura M, Kubota T *, Hidaka E, Wakui K, Kadowaki S, Ueta I, Shimizu T, Ueno I, Yamauchi K, Herzing LB, Nurmi E, Sutcliffe JS, Fukushima Y, Katsuyama T.  Severe Prader-Willi syndrome with a large deletion of chromosome 15 due to an unbalanced t(15;22)(q14;11.2) translocation. Clin Genet 63:79-81, 2003.
        • Hirasawa T, Wada H, Kohsaka S, Uchino S.  Inhibition of NMDA receptors induces delayed neuronal maturation and sustained proliferation of progenitor cells during neocortical development. J Neurosci Res 74:676-687, 2003.
        • Shiraishi K, Itoh M, Sano K, Takashima Y, Kubota T.  Myelination of a fetus with Pelizaeus-Merzbacher disease: immunopathological study. Annal Neurol 54:259-262, 2003.
        • Ida T, Miharu N, Hayashitani M, Shimokawa O, Harada N, Samura O, Kubota T, Niikawa N, Matsumoto N. Functional disomy for Xq22-q23 in a girl with complex rearrangements of chromosomes 3 and X. Am J Med Genet 120A:557-561, 2003.
        • Jo EK,Futatani T, Kanegane H, Kubota T, Lee YH, Jung JA, Song CH, Park JK, Nonoyama S, Miyawaki T. Mutational Analysis of WASP Gene in Two Korean Families with Wiskott-Aldrich Syndrome. Int J Hematol 78:40-44, 2003.
        • Saitoh M, Nagai K, Yaguchi T, Fujikawa Y, Ikejiri K, Yamamoto S, Nakagawa K, Yamamura T, Nishizaki T.  Arachidonic acid peroxides induce apoptotic Neuro-2A cell death in association with intracellular Ca(2+) rise and mitochondrial damage independently of caspase-3 activation. Brain Res 991: 187-194, 2003.
        • Kubota T *, Wakui K, Nakamura T, Ohashi H, Watanabe Y, Yoshino M, Kida T, Okamoto N, Matsumura M, Muroya K, Ogata T, Goto Y, Fukushima Y.  Proportion of the cells with functional X disomy is associated with the severity of mental retardation in mosaic ring X Turner syndrome females. Cytogenet Genome Res 99:276-284, 2002.
        • Nagai K, Jiang MH, Hada J, Nagata T, Yajima Y, Yamamoto S, Nishizaki T.  (-)-Epigallocatechin galllate protects against NO stress-induced neuronal damage after ischemia by acting as an anti-oxidant. Brain Res 956 : 319-322, 2002.
        • Shirohzu H, Kubota T, Kumazawa A, Sado T, Chijiwa T, Inagaki K, Suetake I, Tajima S, Wakui K, Miki Y, Hayashi M, Fukushima Y, Sasaki H. Three Novel DNMT3B Mutations in Japanese Patients with ICF Syndrome. Am J Med Genet 112:31-37, 2002.
        • Wakui K, Toyoda A, Kubota T, Hidaka E, Ishikawa I, Katsuyama T, Sakaki Y, Hattori M, Fukushima Y. Familial 14-Mb interstitial deletion at 21q11.2-q21.3 and variable phenotypic expression. J Hum Genet 47:511-516, 2002.
        • Tada H, Uchino M, Nagai K, Nomura T, Kondoh T, Saito N, Yamamura T, Yajima Y, Nishizaki T.  The anti-dementia drug FK960 stimulates glial glutamate release via a PKA pathway. Brain Res Mol Brain Res 109 : 63-68, 2002.
        • Nishizaki T, Nagai K, Nomura T, Tada H, Kanno T, Tozaki H, Li XX, Kondoh T, Kodama N, Takahashi E, Sakai N, Tanaka K, Saito N.  A new neuromodulatory pathway with a glial contribution mediated via A2a adenosine receptors. Glia 39: 133-147, 2002.
        • Sakashita K, Koike K, Kinoshita T, Shiohara M, Kamijo T, Taniguchi S, Kubota T. Dynamic DNA methylation change in the CpG island region of p15 during human myeloid development. J Clin Invest 108:1195-1204, 2001.
        • Seki H, Kubota T, Ikegawa S, Haga N, Fujioka F, Ohzeki S, Wakui K, Yoshikawa H, Takaoka K, Fukushima Y. Mutation frequencies of EXT1 and EXT2 in 43 Japanese families with hereditary multiple exostoses. Am J Med Genet 99:59-62, 2001.
        • Akahoshi K, Fukai K, Kato A, Kimiya S, Kubota T, Spritz RA. Duplication of 15q11.2-q14, including the P gene, in a woman with generalized skin hyperpigmentation. Am J Med Genet 104:299-302, 2001.
        • Kanegane H, Futatani T, Wang Y, Nomura K, Shinozaki K, Matsukaura H, Kubota T, Tsukada S, Miyawaki T. Clinical and mutational characteristics of X-linked agammaglobulinemia and its carrier identified by flow cytometric assay combined with genetic analysis. J Allerg Clin Immunol 108:1012-1020, 2001.
        • Inoue K, Kanai M, Tanabe Y, Kubota T, Kashork CD, Wakui K, Fukushima Y, Lupski JR, Shaffer LG . Prenatal interphase FISH diagnosis of PLP1 duplication associated with Pelizaeus-Merzbacher disease. Prenat Diagn 21:1133-1136, 2001.
        • Leteux C, Chai W, Nagai K, Herbert C G, Lawson A M, Feizi T.  10E4 antigen of scrapie lesions contains an unusual non-sulfated heparan motif. J Biol Chem 276: 12539-12545, 2001.
        • Hirasawa T, Nakamura T, Mizushima A, Morita M, Ezawa I, Miyakawa H, Kudo Y.  Adverse effects of an active fragment of parathyroid hormone on rat hippocampal organotypic cultures.  Br J Pharmacol 129:21-28, 2000.
        • Wada T, Kubota T, Fukushima Y, Saitoh S. Molecular genetic study of japanese patients with X-linked alpha-thalassemia/mental retardation syndrome (ATR-X).  Am J Med Genet 94:242-248, 2000.
        • Nakane T, Kubota T, Fukushima F, Hata Y, Ishii J, Komiyama A. Opiz Trigonocephaly (C)-like syndrome, or Bohring-Opitz syndrome: Another example.  Am J Med Genet 92:361-362, 2000.
        • Kubota T *, Nonoyama S, Tonoki H, Masuno M, Imaizumi K, Kojima M, Wakui K, Shimadzu M, Fukushima Y.  A new assay for the analysis of X-chromosome inactivation based on methylation-specific PCR. Hum Genet 104:49-55, 1999.
        • Kubota T, Oga S, Ohashi H, Iwamoto Y, Fukushima Y. Borjeson-Forssman-Lehmann syndrome in a woman with skewed X-chromosome inactivation. Am J Med Genet 87:258-261, 1999.
        • Nakajima K, Sakurai A, Kubota T, Katai M, Mori J, Aizawa T, Fukushima Y, Hashizume K. Multiple Endocrine Neoplasia Type 1 Concomitant with Prader-Willi Syndrome: Case Report and Genetic Diagnosis. Am J Med Sci 317:346-349, 1999.
        • Kanai N, Yanai F, Hirose S, Nibu K, Izuhara K, Tani T, Kubota T, Mitsudome A.　 A G to A transition at the last nucleotide of exon 6 of the gc gene (868G>A) may result in either a splice or missences mutation in patients with X-linked severe combined immunodeficiency. Hum Genet 104:36-42, 1999.
        • Fang P, Lev-Lehman E, Tsai TF, Matsuura T, Benton CS, Sutcliffe JS, Christian S, Kubota T, Halley DJ, Meijers-Heijboer H, Langlois S, Graham JM Jr, Beuten J, Willems PJ, Ledbetter DH, Beaudet AL. The spectrum of mutations in UBE3A causing Angelman syndrome. Hum Mol Genet 8:129-135, 1999.
        • Kubota T, Sakurai A, Arakawa K, Shimazu M, Wakui K, Furihata K, Fukushima Y. Identification of two novel mutations in the OCRL1 gene in Japanese families with Lowe syndrome. Clin Genet 54:199-202, 1998.
        • Das S, Kubota T, Song  M, Daniel R, Berry-Kravis EM., Prior TW,  Popovich B, Rosser L, Arinami T, Ledbetter DH.  Methylation analysis of the fragile X syndrome by PCR. Genetic Test1:151-155, 1998.
        • Christian SL, Bhatt NK, Martin SA, Sutcliffe JS, Kubota T, Huang B, Mutirangura A, Chinault AC, Beaudet AL, Ledbetter DH. Integrated YAC contig map of the Prader-Willi / Angelman region on chromosome 15q11-q13 with average STS spacing of 35 kb. Genome Res 8:146-157, 1998.
        • Kubota T, Das S, Christian SL, Baylin SB, Herman JG, Ledbetter DH. Methylation-specific PCR symplifies imprinting analysis. Nat Genet 16:16-17, 1997.
        • Nagai K, Ihara Y, Wada Y, Taniguchi N.  N-glycosylation is requisite for the enzyme activity and Golgi retention of N-acetylglucosaminyltransferase III. Glycobiology 7: 769-776, 1997.
        • Sutcliffe JS, Jiang Y, Galijaard RJ, Matsuura T, Fang P, Kubota T, Christian SL, Bressler J, Cattanach B, Ledbetter DH, Beaudet AL. The E6-AP ubiquitin-protein ligase (UBE3A) gene is localized within a narrowed Angelman syndrome critical region. Genome Res7:368-377, 1997.
        • Kubota T, Sutcliffe JS, Aradhya S, Gillessen-Kaesbach G, Christian SL, Horsthemke B, Beaudet AL, Ledbetter DH. Validation studies of SNRPN methylation as a diagnostic test for Prader- Willi syndrome.  Am J Med Genet 66:77-80, 1996.
        • Kubota T, Aradhya S, Macha M, Smith ACM, Surh LC, Satish J, Verp MS, Nee HL, Johnson A, Christian SL, Ledbetter DH. Analysis of parent-of-origin specific DNA methylation at SNRPN and PW71 in tissues: implication for prenatal diagnosis. J Med Genet 33:1011-1014, 1996.